![]() We aimed to design a 68Ga-labeled FAPI dimer (denoted as 68Ga-DOTA-2P(FAPI)2) to optimize the pharmacokinetics and evaluate whether this form is more effective than its monomeric analogs. However, these molecules have relatively short tumor-retention time for peptide-targeted radionuclide therapy applications. FAP-targeted molecular imaging agents, including FAP inhibitor (FAPI)-04 and FAPI-46, have shown promising results in tumor diagnosis. Fibroblast activation protein (FAP) is overexpressed in CAFs. ![]() ![]() Cancer-associated fibroblasts (CAFs) are crucial components of the tumor microenvironment.
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